EPITHELIAL AND STROMAL COMPONENTS IN DUCTAL BREAST CANCER

Currently, most of the scientific work is focused on the study of epithelial-stromal relations play an important role in the progression of epithelial tumors towards dedifferentiated phenotype. The aim of our research - the study of morphological properties of anaplastic tumor sites and surrounding stroma of ductal breast cancer. Epithelial-stromal interactions in ductal breast cancer cause its aggressive biological behavior, resistance to chemotherapy and varying depending on the survival of tumor differentiation. Heterogeneity is manifested in the ductal carcinoma anaplastic appearance (sarcomatoid) component, which traced the ability of epithelial tumor cells acquire the properties of mesenchymal cells do not require the stroma and have an aggressive malignant potential impact on survival of patients.