AN ANALYSIS OF PROBABLE MECHANISMS OF ANTIDEPRESSANT ACTIVITY OF NEURONAL N-METHYL-D-ASPARTATE RECEPTOR BLOCKERS

Slow appearance of therapeutic action and partial therapeutic efficiency of used today antidepressants demand otherwise approaches for creation on principle new antidepressants. One from prototypes such drugs is ketamine possessing by capacity fast to suppress the symptoms of refractory depression. However a nature of antidepressant activity did not ascertained decisively. The most popular hypotheses of antidepressant action of ketamine and other N-methyl-D-aspartate receptors blockers were analyzed in this review.