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Influence of the thyroxine on the functional activity of the р-glycoprotein in the experiment
Journal: I.P. Pavlov Russian Medical Biological Herald (Vol.12, No. 4)Publication Date: 2011-12-27
Authors : Yakusheva E.N.; Byryukova A.S.; Shchulkin A.V.; Nikiforova L.V.;
Page : 49-53
Keywords : ;
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Abstract
In the research on the rabbits influence of a L-thyroxine on the activity of the protein- transporter Р-glycoprotein (Pgp) was studied. Activity of the Pgp was investigated on the pharmacokinetics of its marker substrate fexofenadine. It was established that introduction of a L-thyroxine within 14 days lead to dose-dependent rising of Рgp activity.
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