Delta-sleep inducing peptide and neuronal activity in dorsal hyppocampus after ventro-medial hypothalamus stimulation

In male Wistar rats 30 neurons of dorsal hippocampus were analyzed after stimulation of ventromedial hypothalamus and delta-sleep inducing peptide microiontophoretic application. It was shown that half of those neurons responded to this stimulation by the rise of impulsation frequency. These neurons predominantly belonged to rats predisposed to stress. Resistant to stress rats were characterized by the absence of neuronal activation after hypothalamic stimulation. Delta-sleep inducing peptide application increased sensitivity of their neurons to stimulation of hypothalamus.