Research flow cytometric of the DNA content in tumor cells of lung cancer patients with paraneoplastic rheumatic syndromeJournal: I.P. Pavlov Russian Medical Biological Herald (Vol.13, No. 4)
Publication Date: 2012-11-30
Authors : Lysenko S.A.; Kirkilevsky S.I.; Chereshnyuk I.L.;
Page : 128-133
Keywords : ;
The study of the DNA content and cell cycle indicators of tumor cells of 70 lung cancer patients: 30 patients with paraneoplastic rheumatic syndrome (PNRS) and 40 - without manifestations of the syndrome. Found that in tumors of lung cancer patients with PNRS, unlike tumors of lung cancer patients without symptoms of this syndrome are observed higher proliferative activity of tumor cells (S-phase), increased indicators of DNA aneuploidy (DNA index, cell index, aneuploidy index) and also have lower levels of apoptosis. All these changes are indicative of more highly aggressiveness and malignancy of tumor process in lung cancer patients with PNRS.
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