Morpholology of immune system of offspring after stimulation of maternal immune system in early pregnancy

Stimulation of maternal immune system in early pregnancy with Concanavalin A, a T-cell mitogen, prior to formation of fetal immune system impairs development of the offspring’s spleen and thymus. Our findings demonstrate that short-term exposure of pregnant murine dams to Concanavalin A, leads to retardation of postnatal development of offspring’s spleen and reduction of lymphocytes count in thymus medulla and accelerated formation of thymic corpuscles.