SPECIFICS OF POLYMORPHISMS OF GENES OF AGO1, DGCR8, GEMIN4, DROSHA IN PATIENTS WITH HYPERTENSION AND POST-INFARCTION CARDIOSCLEROSIS

A total of 30 men with hypertension and 20 men with post-infarction cardiosclerosis were examined. The analysis of association of polymorphisms of genes which participate in a biogenesis of microRNAs (miRNAs), such as AGO1 (A/G), DGCR8 (G/A), GEMIN4 (A/G), DROSHA (A/C) with a frequency of hypertension and post-infarction cardiosclerosis is carried out. The association between a genotype of AA of a gene of GEMIN4 and risk of development of hypertension is found. The results indicated about important role of this genotype in pathogenesis of hypertension, but mechanisms of realization of its effects aren't studied.