THE EFFECT OF SPECIFIC PHARMACOTHERAPY ON THE DEGREE OF OXIDATIVE MODIFICATION OF PROTEINS AND LIPIDS IN THE BLOOD PLASMA OF PATIENTS WITH KNEE OSTEOARTHRITIS

Knee osteoarthritis is followed by the intensification of free radical oxidation of proteins and lipids in the blood plasma of patients. Specific pharmacotherapy leads to a significant reduction in the content of carbonyl groups, aliphatic aldehyde groups and malondialdehyde in the tested samples, and to an increase in the total protein content up to normal physiological values in half of the treated patients. The results of the study allow us to recommend the use of these indicators in laboratory diagnostics for indepth study of the degenerative dystrophic process in the knee joint, as well as to monitor the progress of therapy and to evaluate the effectiveness of therapeutic interventions.