INDUCERS OF THE REGULATORY FACTOR TO HYPOXIA ADAPTATION
Journal: I.P. Pavlov Russian Medical Biological Herald (Vol.22, No. 2)Publication Date: 2014-06-27
Authors : Levchenkova O.S.; Novikov V.E.;
Page : 133-143
Keywords : ;
Abstract
The review is devoted to the analysis of the modern conceptions about role of specific regulatory protein HIF-1α (hypoxia-inducible factor-1alpha) in the mechanisms of adaptation to hypoxia. Experimental and clinical results of using of different HIF-1α inducers (inhibitors of HIF-1α degradation and inactivation, activators of transcription and translation of HIF-1α) to activate the processes of immediate and delayed organism adaptation to hypoxia is discussed in the article. This approach opens promising opportunities for effective pharmacotherapy of cardiovascular and other diseases with hypoxia and ischemia in their pathogenesis.
Other Latest Articles
- THE METHOD OF QUANTITATIVE EVALUATION OF SOME PARA-AMINOPHENOL DERIVATIVES IB PHARMACEUTICAL AND CHEMICO-TOXICOLOGICAL INVESTIGATIONS
- The form and the disposition of the lower border of the maxillary sinus at the physiological, mesial and distal occlusion of dentition
- IMPACT ASSESSMENT OF SURGICAL DAMAGE DURING PERFORMING INGUINAL HERNIOPLASTY TO THE FUNCTIONAL STATE OF THE TESTIS AND POTENTIAL OF THE FERTILITY
- INTRAVENOUS LASERTHERAPY AND INTERVAL NORMOBARIC HYPOXYTHERAPY EFFECTIVENESS IN ASTHMA AND COMORBID ESSENTIAL HYPERTENSION COMPLEX THERAPY
- ANALYSIS OF THE EFFICACY AND SAFETY OF THROMBOLYTIC THERAPY OF ACTILYSE IN PATIENTS ELDERLY AND SENILE AGE WITH MYOCARDIAL INFARCTION WITH ST-SEGMENT ELEVATION
Last modified: 2016-03-30 07:32:25