INFLUENCE OF ANTIHYPOXANTS ON THE DEVELOPMENT OF CARRAGEENIN-INDUCED INFLAMMATION

In the experiment, on a model of acute carrageenin-induced inflammation of rat’s paw, changes in size of the affected limbs (paw edema), parameters of leukogram and activity of free radical oxidation were registered. The anti-inflammatory effect of antihypoxants (amtizol, hesperidin, hypoxen, metaprot) was investigated. It has been shown that hypoxen and metaprot 50 mg/kg have weak anti-inflammatory activity, but potentiate the effect of nonsteroidal anti-inflammatory drugs. At simultaneous enteral administration of hypoxen and metaprot with acetylsalicylic acid or diclofenac, evident anti-inflammatory effect was marked, that was manifested by significant reduction in registered inflammation symptoms.