ANTI-MICROBIAL ACTIVITY OF SOME HETEROCYCLIC SULPHONAMIDE DERIVATIVES

In the present study, some heterocyclic sulphonamide derivatives were synthesized by using condensation reaction.The synthesized and characterization of 4-((phenyl(2-phenylimidazo[4,5-b]indol-3(4H)- yl)methyl)amino)benzenesulfonamidederivatives. All the synthesized compounds were characterized by UV, IR, 1H NMR, and mass spectroscopy. The synthesized compounds were screened for their in-vitro anti-bacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumonia and in-vitro anti-fungal activity against Candida albicans, Aspergillus niger by agar well diffusion method.All the compound were found to possess significant anti-microbial activity.The compounds DD4,DD5,DD6 showed potent anti-bacterial activity compared with standard drug Amikacin and the compounds DD1,DD2,DD3 showed potent anti-fungal activity compared with standard drug ketoconazole. Key Words: Sterile petriplates , ,ketoconzole, Amikacin, sterilized petri dishes, DMSO.