The study of correlation between dyslipidemia and hypertension and its complications in 30-70 years age group

Background: Dyslipidemia and hypertension were the two widely recognized independent key risk factors for development of coronary vascular disorders (CVD). Therefore, Dyslipidemia and hypertension can serve as an easy clinical approach to know persons at greater risk for the and timely interference directed to decrease CVD events. To this purpose, we studied the correlation between dyslipidemia and hypertension and its complications among 30-70 years age group in a tertiary care hospital in Andhra Pradesh. Materials and methods: The present work was a hospital based, analytical cross sectional study conducted in the department of General Medicine in a tertiary care hospital at Andhra Pradesh over the period of two years from October 2012 to September 2014. A total of 100 HTN patients and 50 non hypertensive controls were recruited for the study. The patients were in the range of 30-70 years age group. Both known hypertensive patients who were on treatment for a varying period of time and newly diagnosed hypertensive patients were included in the study. The hypertensive and healthy controls were selected in to the study by systematic random sampling. A structured and validated designed case report form (CRF) was used for data collection. The tool was validated by including the inputs from five experts in the subject area. The blood samples were drawn from all the patients after 10 to 12 hours of fasting. FBS, PPBS and Lipid profile values were obtained as per the prescribed standards. Descriptive analysis of demographic and relevant clinical parameters was done. Various serum lipid levels were considered as primary outcome variables. Categorical variables were presented as frequencies and percentages. Results: There were 100 hypertension patients and 50 controls were included in the final analysis. Among the hypertension patients 86% of them were males and 14% were females. The HDL value was lower in hypertensive patients, compared to control group (39.78±6.37 Vs 54.5±4.2). Statistically significant difference was observed in total cholesterol, LDL cholesterol, TC/HDL ratio and LDL/HDL ratio between obese and non obese as well as in CVA, IHD among hypertensive patients relatively with healthy volunteers. Conclusion: Biochemically there was significant difference was observed in total cholesterol, LDL cholesterol, TC/HDL ratio and LDL/HDL ratio between obese and non obese hypertensive patients. The similar discrepancy was noticed in CVA, IHD patient population. The HDL value was low down in all hypertensive patients compared to control group.