Fabrication and characterization of Metformin loaded floating microspheres

The aim of this study was to fabricate and characterize Metformin hydrochloride floating microspheres using Eudragit RS100 as a polymer. Microspheres were prepared by non-aqueous solvent evaporation method using ethanol/liquid paraffin system. The influence of formulation factors (drug: polymer ratio, stirring speed, concentration of surfactant) on particle size, encapsulation efficiency and in vitro release characteristics of the microspheres were investigated. The yields of preparation and encapsulation efficiencies were high for all formulations obtained. Mean particle size changed by changing the drug: polymer ratio or stirring speed. Although Metformin hydrochloride release rates from Eudragit RS100 microspheres were decreased as the concentration of Eudragit RS100 increased. By applying one way ANOVA followed by Newman-Keuls Multiple Comparison value obtained (p< 0.05) was considered to be statistically significant.