Von Economo neurons: A Review of the Anatomy and Functions

Von Economo neurons (VENs) are large bipolar neurons found in the anterior cingulate, frontoinsular and dorso-lateral prefrontal cortices of great apes and the humans. VENs are defined by their thin, elongated cell body and long dendrites projecting from the apical and basal ends. These neurons are mostly present in particularly high densities in cetaceans, elephants, and hominoid primates mainly, humans and apes. VENs have been shown to contribute in the specializations of neural circuits in species that share both large brain size and complex social cognition due to their location. This could possibly be due to the adaptation to rapidly relay of socially-relevant information over long distances across the brain. The VENs have been shown to be recently evolved cell type which may be involved in the fast intuitive assessment of complex social situations. As such, they could be part of the circuitry supporting human social networks. The VENs emerge mainly after birth and increase in number until four years of age. The presence of VENs in the frontoinsular cortex has been linked to a possible role in the integration of bodily feelings, emotional regulation and goal-directed behaviors. Some studies have shown decreased number of VENs in neuropsychiatric diseases in which social cognition is markedly affected. Some researchers have shown that selective destruction of VENs in the early stages of frontotemporal dementia implies that they are involved in empathy, social awareness, and self-control which is consistent with evidence from functional imaging.