Dispersive Liquid-liquid Microextraction-injector Port Silylation: A Viable Option for the Analysis of Polar Analytes using Gas Chromatography-Mass Spectrometry

Analysis of analytes with polar functional groups using gas chromatographymass spectrometry pose challenges due to adsorption of these analytes on the active sites of injector port and capillary column. These can be overcome by performing derivatization. An attempt has been made to review the literature to understand the injector port derivatization (particularly silylation) coupling with dispersive liquid-liquid microextraction for the analysis of polar analytes and its use in the analysis of chemical analytes containing polar functional groups.