ASSOCIATION BETWEEN APOLIPOPROTEIN E GENE POLYMORPHISM AND HEART FAILURE AMONG DIABETIC ELDERLY PATIENTS

Aim : Study association between Apo E polymorphism and development of heart failure among diabetic patients. Material and methods : case control study conducted on 90 elderly participants and they were classified into three groups each had 30 participants first group diabetic with atherosclerotic complications, second was diabetics without any complications while third group was non diabetics as control all of them were subjected to assessment of blood sugar and lipid profile and Ap o E allele detection as well as Echocardiography for assessment of heart failure. Results : study showed that among diabetic patients with atherosclerotic complication there is increased incidence of heart failure more than diabetic without complications or non - diabetic patients and that incidence of heart failure is higher among those carrying Apo E4 allele. Conclusion : the study concluded that Apo E4 allele is associated with increased risk of development of heart failure among diabetic patient mostly due to effect of Apo E4 on lipid metabolism and atherosclerotic process