STUDYING THE RELATIONSHIP BETWEEN INSULIN GROWTH FACTOR 1, C - REACTIVE PROTEIN AMONG DIABETIC FRAIL ELDERLY

Objective : to study the relationship between Insulin Growth Factor 1(IGF - 1) and C - reactive protein (CRP) among diabetic frail elderly Methods : A case control study has been carried on 90 elderly aged 60 years and over, collected from (Mansora university hospital & community dwe lling elderly) during the period January 2015 - July 2015. Subjects were divided into: Control group of 30 healthy elderly and cases group: of 60 frail elderly which is furtherly subdivided into two subgroups: frail with diabetes and frail without diabetes . S ubjects were subjected to comprehensive geriatric assessment and study of osteoporotic fractures (SOF) index for assessment of presence of frailty. Results : IGF - 1 level was significantly lower among the frail patient. Also , IGF - 1 level was significantly lower among diabetic frail elderly. In addition, CRP level, significantly higher among frail elderly but there was no significant statistical difference between the frail diabetic & frail non diabetic as regards the CRP level. Concl usion : F rail elderly had a lower IGF - 1 level and a higher CRP level in compare with control participant. Also , diabetic frail elderly had significantly lower IGF - 1 level compared to the non - diabetics. However there was no difference between CRP level among diabetic and non - diabetic frail elderly .