Bone Remodeling and Biomechanical Processes- A Multiphysics Approach

Bone remodeling is bone’s mechanism to optimize its structure in response to the body’s external and internal stimuli. From the mineralized matrix of whole bone to the lacuna canalicular network of osteocytes, mechanical and biological signaling induce changes in properties like bone density. Previous studies have made strides in simulating aspects of these processes with mathematical models. The focus is to now create a more encompassing assessment by incorporating the interdependence between bone’s macrostructure and microstructure. This work is emphasizing a multiphysics and multiscale approach in creating a model to predict the age-related changes in bone remodeling.