SOME MECHANISMS OF FUNCTIONING DISORDERS IN HEPATIC MITOCHONDRIAL ENZYMATIC SYSTEM FOR TOXIC HEPATOSES AND POSSIBLITY TO CORRECT THEM WITH BERBERINE BISULPHATE

CsA-pore of hepatic mitochondria transfers into an opener status for chronic heliotrine hepatitis with transition into cirrhosis. Stage phrmacotherapy with berberine bisulphate reduces hyperenzymemia, hyperbilirubinemia, hypercholesterolemia and increases the content of total protein and albumins in blood serum of rats and rabbits. The mentioned changes coincide with reduction of inflammatory-destructive processes and decelerating progressing cirrhotic changes in the liver. This preparation decreases permeability of mitochondrial membranes for calcium ions, restores functional status of respiratory chain of disturbances mitochondria, reduces hyperlipoperoxidation and increases AOD enzymes' activity.