ANALYSIS OF CYP2C19POLYMORPHISMS AS GENETIC RISK FACTORS FOR HEMATOLOGICAL MALIGNANCY OF THE POPULATION SOUTHERN IRAQ

The present study aimed to detect the role of CYP2C19 gene and its relationship in the incidence of hematological malignancies of the Population Southern Iraq, through the use of PCR- RFLP technique, were collected 120 blood samples (from oncology center/AL-Habboubi Teaching Hospital in Thi-Qar and specialized center of hematology and oncology cancer/Al-Sadr Teaching Hospital in Basra) in tubes EDTA from patients with hematological malignancies ages ranging between (15 - 90 years) and 50 samples from healthy people ages ranging between (15 ? 80 years) and saved directly at a temperature of - 20 ° C Later to be used for the extraction DNA and the PCR technique results of statistical analysis. Showed no correlation between polymorphism of the gene CYP2C19 and the incidence of hematological malignancies when compared to patients a range of comparison And each of the mutant homogenized style (AG) (OR=0.64 ; 95%CI=0.31-1.30)The style of the mutant differential (GG) (OR= 0.42; 95%CI=0.21-0.83). It was evident from the results that females who have the mutant heterozygous (AG) has increased their risk of congenital heart defects by deference (OR = 1.86) and the period of confidence (0.65 - 5.27), and the results also showed that those who have the heterozygous differential (AG) and category age (month - 9 years) have increased the risk of congenital heart defects by teams (OR = 3) and the period of confidence (0.8 ? 12). and the results showed no correlation between smoking and multiple genotypes of the gene CYP2C19.