DESIGN AND INVITRO EVALUATION OF ESOMEPRAZOLE BUCCOADHESIVE TABLETS

The present research was formulation and evaluation of Esomeprazole buccoadhesive tablets, Bioadhesion may be defined as the state in which two materials, at least one of which is biological in nature, are held together for extended periods of time by interfacial forces. In the pharmaceutical sciences, when the adhesive attachment is to mucus or a mucous membrane, the phenomenon is referred to as mucoadhesion amongst the various routes of drug delivery, oral route is perhaps the most preferred to the patient and the clinician alike. Transmucosal routes of drug delivery (i.e., the mucosal linings of the nasal, rectal, vaginal, ocular, and oral cavity) offer distinct advantages over peroral administration for systemic drug delivery. These advantages include possible bypass of first pass effect, avoidance of presystemic elimination within the GI tract and depending on the particular drug, a better enzymatic flora for drug absorption. . Tablets were evaluated their compatibility studies by using FT-IR, micrometrics properties, post formulation characters such as hardness, thickness, friability, content uniformity, Ex vivo mucoadhesive strength and in-vitro dissolution studies. Key Words: Esomeprazole, Trans mucosal, Buccoadhesive, Mucoadhesion