THE INFLUENCE OF PROINFLAMMATORY CYTOKINES ON EXTERNAL RESPIRATION SYSTEM

Based on analysis of the literature and our own experimental data, participation of cytokines, mediators of the immune system, in central mechanisms regulating physiological functions is discussed. It is shown that the increase of content of the main pro-inflammatory cytokine IL-1β in the blood stream activates the central mechanism of breathing pattern regulation while simultaneously reducing ventilatory sensibility to hypoxemic and hypercapnic changes of blood gas. The role of cyclooxygenase mechanism providing respiratory effects of IL-1β is described. The conclusion about the negative impact of enhanced expression of pro-inflammatory cytokines on the respiratory system at pathological conditions accompanied by a sharp increase in the level of pro-inflammatory cytokines in an organism (systemic inflammation, brain injury, stroke, ischemia, etc.).