Carboplatin - based chemotherapy in advanced ovarian cancer

Eight patients of advanced ovarian cancer were treated with monthly cycles of Ifosfamide, Adriamycin and Carboplatin. Debulking surgery was done in 7 cases. None of the patients had complete response. All eight patients had partial response. The follow-up was for 36 months. The present protocol appears to have an influence on initial control of disease but relapse continue to occur following the treatment. Cytoreductive surgery before or after three cycles of chemotherapy may have favourable influence on disease free survival (DFS). Second, third, fourth look surgeries have good results in many centers, which is not routinely practised at this center, might be the main reason for the poor outcome. Prolonged follow up along with second, third, fourth look surgeries will be necessary to determine the overall influence on long term survival.