DEFEROXAMINE ACCELERATED HEALING IN OPEN EXCISION WOUND MODEL IN RATS

Forty apparently healthy male Wister rats were used in this study and full thickness cutaneous wounds were created under pentobarbitone anesthesia. All the rats were divided into two groups, of which one (control) was treated with ointment base and other with DFO ointment (0.1%). Wound size measurement and tissue collection were done on days 3, 7, 11 and 14 post-wounding. Histopathological changes were assessed by H&E staining. The percent wound healing was significantly higher on days 7, 11 and 14 in DFO-treated rats as compared to control. DFO markedly facilitated cutaneous wound healing in rats by recruitment of inflammatory cells, deposition of fibroblasts, formation of new blood vessels and epithelialization to the wound site. Therefore, topical application of DFO ointment might be of great use in cutaneous wound healing in rats.