Poems Syndrome: A Rare and Relatively Unknown Disease

POEMS syndrome is a rare paraneoplastic syndrome associated with plasma cell dyscrasia. We report a case of solitary plasmacytoma with osteosclerotic lesion in a 53 year-old man treated with local radiotherapy. After four years, the patient experienced peripheral polineuropathy, cutaneous hyperpigmentation, evidence of multiple bone lesions on CT scan, deep venous thrombosis of the lower extremities, and the presence of a serum M protein. The patient was diagnosed with POEMS syndrome. He received a double highdose melphalan with autologous stem-cell support which was followed by a systemic and hematologic improvement. Plasmacytoma is very rare as an initial manifestation of POEMS syndrome. Patients presenting with plasmacytoma and an osteosclerotic lesion should be carefully observed and evaluated for the possible development of POEMS syndrome, as most bone plasmacytomas in POEMS syndrome patients are reported to be osteosclerotic