Tuberous Sclerosis and Substance Abuse: A Case Report

Tuberous sclerosis complex is a neurocutaneous disorder with significant neuropsychological implications, especially with regards to epilepsy and cognition and characterized by a wide phenotypic spectrum, occurring in approximately 1 in 6000 to 10,000 individuals. The diagnosis of tuberous sclerosis complex is based on the lesions found on clinical examination, imaging, and pathological studies. Clinical manifestations are present according to organ systems. The type, size, number, and sometimes the location of involved lesions and organ systems indicate the clinical presentations. Clinicians must take in consideration the management of the clinical features of the disease and understanding of the pathogenesis and pathophysiology. Here we report a case of tuberous sclerosis complex with involvement of skin, eye, heart, kidney, and brain. Intellectual disability and impulsivity, complicated with epilepsy history and substance abuse that increases criminal tendencies are the significant aspects of the case that should be discussed.