Ischemic Vascular Events as Clinical Manifestation of Protein C Deficiency

We report three patients who suffered from recurrent vascular ischemic events associated with a protein C deficiency to highlight the importance of evaluating protein C activity in young patients of recurrent vascular events without major risk factors. Protein C deficiency presenting with cerebral ischemic has been only rarely observed. Anticoagulation therapy combined with fresh frozen plasma in the acute phase received good curative effect. These three cases indicate that the determination of protein C levels is valuable in the evaluation of patients with recurrent vascular events. Early diagnosis and treatment can prevent severe consequences.