PRO-OXIDANT-ANTIOXIDANT CHANGES IN DIFFERENT PARTS OF SMALL INTESTINE IN COURSE OF EXPERIMENTAL SUBHEPATIC OBSTRUCTIVE JAUNDICE

The aim of the study was to investigate lipid peroxidation and antioxidant defense state in different parts of rat small intestine in the course of experimental subhepatic obstructive jaundice. The experiment was carried out on 65 mongrel white male rats weighting 250 ± 30g. A total of 4 sets of experimental subhepatic obstructive jaundice models of different duration were produced. False operated rats served as a control group. The obtained data show that prolonged ligation of the common bile duct leads to a steady and significant elevation of common bile acid serum concentration, producing cytotoxic effects on parenchymatous elements of small intestine layers on different levels, which, in turn, causes changes in lipid peroxidation and antioxidant defense state in different parts of the small intestine.