SERUM LEVELS OF CALCIUM, PHOSPHOROUS, VITAMINE “D” AND PRATHYROID HORMONE IN INDIVIDUALS WITH PRIMARY HYPERPARATHYROIDISM IN ALBANIA

To assess the present situation of laboratory profile of the individuals diagnosed with primary hyperparathyroidism in Albania. Primary hyperparathyroidism is characterized by incompletely regulated, excessive secretion of parathyroid hormone (PTH) from one or more parathyroid glands. Hypercalcaemia, hypophosphatemia and deficiency of vitamin D is caused in cases of increased PTH levels. 125 patients, aged 18-78 years diagnosed for primary hyperparathyroidism in the University Hospital “Mother Theresa “ in Tirana from 2009 to 2011 were enrolled in the study. A 10 ml fasting blood sample was collected in pre-chilled tubes for determination of PTH and 25- hydroxyvitamin D, as well as other biochemical parameters. Serum concentration of 25(OH) D and PTH were measured by Electrochemiluminescence immunoassay on Roche Coobas 6000 system. The mean (SD) age was 43.5 (14.14) years (range 18-72): Mean (SD) body weight was 55.7 kg (range 36-78). The mean serum calcium concentration was 12.47(1.58) mg/dl; 12 patients had the serum calcium < 8.6; 37 had the serum concentration 8.6-10.2 mg/dl and 76 had the serum concentration > 10.2 mg/dl. Serum phosphate level fell to 2.1 mg/dl. 39% of the patients had severe vitamin D deficiency (serum 25 OH D,