Conversation between Mitochondria and Nucleus: Role of FEN1 and ING1 in Association with the Ringmaster PCNA

Mitochondria and nucleus maintain collaboration during apoptosis and oncogenesis where two machineries FEN1 and ING1 are playing major role in the theatre of DNA metabolic pathway in concomitant with the metabolic actor PCNA. PCNA, FEN1 and ING1 localized in mitochondria and nucleus by forming a larger protein complex, potentially involved in the regulation of DNA damage repair, apoptosis and cancer. But the mechanism of these proteins migration and coordination between mitochondria and nucleus is unknown. Understanding the signaling across sub-cellular location based on FEN1/ING1/PCNA might lead to interlink the molecular regulation of cell death and immortalization within the mitochondrial and nuclear location.