AREA UNDER CUR VE UV SPECTROPHOTOME TRIC METHOD FOR THE DETERMINATION OF CEFPODOXIME PROXE TIL IN SINGLE COMPONENT TABLETS

An UVspectrophotometric area under curve method is developed for the estimation of Cefpodoxime Proxetil in its single component tablets. The new method is area under curve method for the analysis of Cefpodoxime Proxetil using methanol as solvent for the drug. Cefpodoxime Proxetil has absorbance maxima at 235nm at area under curve wavelength ra nge of 230nm - 240nm. Cefpodoxime Proxetil obeys Beer’s law in concentration range 10 - 50μg/ml. The r ecovery studies ascertained accuracy of the proposed method; results validated according to ICH guideline. Results were found satisfactory and reproducible. The method was successfully for evaluation of Cefpodoxime Proxetil in tablet dosage form without in terference of common excipients.