ANTICANCER ACTIVITY AND DRUG LIKELINESS OF QUINOLINE THROUGH INSILICO DOCKING AGAINST CERVICAL AND LIVER CANCER RECEPTORS

The oncogenic protein receptors were key molecular targets for cancers. Especially in tumor cells, they were frequently transformed or mutated at abnormal states. The normal cells encounter a programmed cell death (apoptosis). It is an imperative and striking focus for anticancer medication advancement and disclosure. Biophytum sensitivum is a medicinal plant rich in quinoline and amentof lavone. The aqueous extract of plant was still administered for various ailments in naturopathy medicines. Quinoline is a versatile heterocyclic compound used to anti - inflammatory and anti - malarial properties. The quinoline was evaluated for the drug lik eliness score and insilico anticancer activity against liver and cervical cancer receptors. In this present study the 5 cervical (4K3J, 4COX, 4J96, 1PRH, 1YY9) and 4 liver cancer receptors (3S35, 3S37, 3LVQ, 4X47) were docked with quinoline through in sili co docking. 4K3J and 1yy9 of cervical receptors indicated that the quinoline ligand inhibited significant inhibition than other receptors of the cervical cancer. Similarly liver receptors 3S35 and 4X47 were significantly inhibited by quinoline inhibitor. The drug likeliness score of quinoline indicates the best score attained as - 0.53.