Probiotics: Insights on Probiotic Effects and Next Generation Therapy to Combat Inflammatory Bowel Diseases

Probiotics are live organisms that exert a health benefit on the host, have been used for the management of a range of gastrointestinal disorders, though there have little evidence. Interest in intestinal microflora is increased because of its effect on various gastrointestinal disorders. Inflammatory Bowel Diseases (IBD) is a complex, multifactorial, and the most frequent gastrointestinal disorders all over the world. In more recent time, Probiotics have been explored as a possible treatment for IBD and other gastrointestinal diseases. The mode of action of probiotics has not been fully elucidated. The acceptance of probiotics has been better gradually due to the development of modern molecular methods and well-controlled experimental trials of the results of probiotics on IBD to scrutinize and recognize multifarious bacteria within human intestines. The Probiotic strains, molecular mechanism of probiotic action on human intestine, Probiotic action on IBD disease etiology are reviewed. The effect of probiotics on different gastrointestinal disorders and the consequences from experimental trials of probiotics for the treatment of such disorders are also summarized. These areas of research have great potential and deserve more experimental study at all levels.