PROGNOSTIC SIGNIFICANCE OF ANGIOGENESIS MARKER EXPRESSION IN LOW-GRADE CANCER OF THE DISTAL COLON

Survival of patients with distal colon cancer, despite a higher degree of tumor differentiation and its early detection, is lower than in proximal colon cancer. Objective: To evaluate the survival of patients with low-grade cancer of distal colon stage I-III depending on the level of expression of markers of angiogenesis in tumors. Materials and Methods: Forty-four cases of cancer were studied immunohistochemically with the assessment of the expression of markers of angiogenesis. Results: Survival over 5 years in stage I-IIA may be expected when VEGF?0.98 or TGF-β?0.83, or NRP1> 0.655. While in stage IIIA-C patients ? when the level of MMP-2?0.034.