ANALYSIS OF THE FREQUENCY OF SOME POLYMORPHISMS OF THE CYTOKINE GENES IL-10, IL-4, TNF IN PATIENTS WITH CHRONIC HEPATITIS B

The aim of the present study was to compare the frequency of IL-10 (G1082A), IL-4 (C589T) and TNFα (G308A) gene polymorphisms in healthy individuals and patients with chronic hepatitis В (CHB), belonging to ethnically homogenous group of residents of the Odessa region. Cytokine gene polymorphism was studied by means of amplification of the respective portions of the genome using PCR method. The structure of the primers used and the parameters of the temperature cycles were taken from the international genomic database. We found significant differences in the frequency of polymorphism of the above genes in the groups of healthy individuals and those with CHB, which may further serve as one of the genetic criteria of hepatitis В progression.