USAGE OF VARIOUS CONCENTRATIONS OF KETAFOL FOR DILATATION AND CURETTAGE

Background:Ketafol is a combination of Ketamine and Propofol in different proportions. Various gynecological techniques are short periods and need only pain relief with moderate sedation. Aim:To compare the benefit of Ketafol with different concentration in dilatation and curettage regarding onset of sedation, level of sedation, recovery time, post operative pain and surgeon satisfaction score. Methods:Our respective investigation includes 104 adult female patients, aged 20-38 years, classed I by the American Society Of Anesthesiologists and planned for elective Dilatation and Curettage procedure with a period of surgical intervention not more than 15 min, during the period Jan 2015 - Mar 2016, at Prince Hashim hospital, Zarqa, Jordan, after obtaining approval from our Ethics and research board review Committee of the Royal Medical Services and written informed consent from all participants. Patients were divided into two groups: group (I, n=51) given Ketafol containing Ketamine: Propofol (1:1) while group (II, n=53) given Ketafol containing Ketamine: Propofol (1:2) .Then we compare two groups regarding onset of sedation, level of sedation using Ramsey sedation scale, recovery time using modified Aldrete score, post operative pain using verbal rating scale and surgeon satisfaction score. Results: Ketofol in groups I and II was similar in onset of sedation (GI: 1.46 ± 0.45 min, GII: 1.47 ± 0.59 min), intraoperative Ramsey sedation scores at 10 min (GI: 5.47 ± 0.37, GII: 5.72 ± 0.24) and recovery times (GI: 3.87 ± 0.88 min, GII: 3.42 ± 0.54 min). Regarding the onset of sedation, intraoperative sedation score and recovery time, there were no remarkable differences between the groups. Conclusion:Ketofol in a proportion of 1:2 induces better sedation level in comparison to the other group, both ketofol concentrations (1:1 and 1:2) are comparable regarding sedation profile in dilatation and curettage procedures.