FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLETS OF METOPROLOL SUCCINATE

In the present work efforts have been made to develop immediate release tablets of Metoprolol succinate using direct compression technique involving super disintegrants like croscaremallose sodium, sodium starch glycolate. The pre compression parameters like angle ofrepose , bulk density, true density, compressibility index are within the IP limit. The post compression parameters are acceptable and within the IP limit. In-vitro drug release at for all the formulations was found to be 95 to 99% and was satisfactory. The optimized formulation F6 (10% sodium starch glycolate) of drug release was found to be is 99% at 30 min . Key words: Immediate release, Super Disintegrants and bioavailability.