IMPACT OF IL17A, IL10, IL1B GENES POLYMORPHISM ON PRODUCTION OF EPONYMOUS CYTOKINES IN KAZAKH POPULATION

Research is aimed at impact assessment of IL17A (rs8193036, rs2275913), IL10 (rs1800872), IL1B (rs1143627) genes polymorphism on production of eponymous cytokines in patients with hepatocellular carcinoma of viral etiology and chronic viral hepatitis in Kazakh population. The total number of study participants is 211 men of Kazakh nationality, including 65 patients with diagnosis of hepatocellular carcinoma of viral etiology, 57 men with diagnosis of chronic viral hepatitis В or С and control group amounted 89 men. It has been established that rs1800872 polymorphism of IL10 gene raises the production of the IL-10 cytokine at АС genotype in patients with chronic viral hepatitis in Kazakh population(р=0.04). The statistically significant lack of influence of IL1В gene rs1143627 polymorphism on production of IL-1β cytokine and lack of influence of rs8193036, rs2275913 polymorphisms of IL17A gene on IL-17А production in patients with hepatocellular carcinoma of viral etiology and chronic viral hepatitis in Kazakh population has also been proved.