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The Efficacy of Hyaluronic Acid Gel in Pain Control of Recurrent Aphthous Stomatitis

Journal: International Journal of Dentistry and Oral Science (IJDOS) (Vol.03, No. 06)

Publication Date:

Authors : ; ; ; ; ;

Page : 273-275

Keywords : Hyaluronic Acid; Triamcinolone Acetonide; Recurrent Aphthous Stomatitis.;

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This study was conducted to evaluate the efficacy of topical hyaluronic acid gel (HA) and compared with triamcinolone acetonide pomad (TA) in the treatment and pain control of RAS. A total of 57 patients with a history of RAS and currently suffering from oral ulcer were selected from patients referred to clinic. The subjects randomly divided into two groups; one group have received HA gel (Aftamed® Oral gel, AktiFarma. Istanbul, Turkey) the other group conceived TA pomade, (Kenacort-A Orabase® Pomade, 0,1% Triamsinolon acetonide, Bristol-Myers Squibb Ilacları Inc. Istanbul, Turkey). All patients were instructed to apply the agents to the ulcer 4 times per day for 7 days (day 0 to day 6). To evaluate pain level, a visual analog scale (VAS) was used. Although there was no statistical difference between two groups by means of mean ulcer VAS scores (8.57±1.05 in HA group and 8.59±1.08 in TA group) at day 0, significant differences were found at day 4 (VAS score=4.88±0.83 in HA group and 5.82±1.07 in TA group) and day 7 (VAS score=2.30±0.90 in HA group and 3.07±0.97 in TA group). The ulcer pain score (VAS) of two groups decreased within time however, the pain score in HA group was statistically lower than that of the TA groups at day 4 and 7 (p<0.05). HA gel reduced the painfull symptoms of RAS when compared with TA pomad. These outcomes suggest that HA gel can be effectively used for pain control in RAS treatment.

Last modified: 2017-05-29 20:21:02