THE INFLUENCE OF CHRONIC HYPOXIA ON THE ACTIVITY OF LIPID PEROXIDATION PROCESSES IN LYMPHOCYTE MEMBRANES

Clinicians have paid attention to studying the role of activity of lipid peroxidation processes in pathogenesis of chronic hypoxia at severe, uncontrollable bronchial asthma recently. Obstinate inflammation of respiratory tract determines the severity of clinic manifestations of bronchial asthma [9]. In inflammation pathogenesis the leading role belongs to local and systemic hyperproduction of ROI and resulting induction of lipid peroxidation processes [7]. Activation of lipid peroxidation processes, in its turn, promotes stability of chronic obstinate inflammation in respiratory tract [6]. This vicious circle not only leads to the affect of respiratory tract, but also causes the transformation of inflammatory process into chronic one and is the basis of bronchi remodeling process [10].