Ultrathin Multi-layered Nanocapsules of Aminoglycoside for Topical Drug Delivery

The unfolding development in the field of medical sciences have revolutionized the research in the field of advanced drug delivery. Sustained release or controlled release of drug delivery systems are designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of a single dose. These products have been formulated for oral, injectable, and topical use. Several desirable therapeutic advantages can be achieved by using controlled released systems. Since the frequency of drug administration is reduced, patient compliance can be improved. The blood level oscillation characteristic of multiple dosing of conventional dosage forms are reduced, because a more even blood level is maintained. A less obvious advantage, implicit in the design of sustained release forms, is that the total amount of drug administered can be reduced; thus maximizing availability with a minimum dose.