Chemical composition of essential oil of Hyptis suaveolens (L.) POIT and its invitro anticancer activity

The present investigation aimed to evaluate the chemical composition of essential oil of the leaves of Hyptis suaveolens (L.) and its invitro anticancer activity. The hydrodistilled essential oil of H.suaveolens contains total of 24 components by GC-MS analysis. The major compounds of H. suaveolens were Sabinene (29.42%), Trans caryophyllene (13.66), E-spathulenol (7.10%), Rimuene (5.73%), the minor compounds were 1,8-Cineole (4.61%), β-Elemene (4.25%), Eucaliptol (3.00%), Bergamotol ,Z-α-trans (2.47%), α-Selinene (2.32%), Caryophyllene oxide (2.08%), γ-Elemene (1.97%), α-Humulene (1.37%). The obtained essential oil was tested against Human breast cancer cell line (MCF-7) for its anticancer activity by MTT assay with different concentrations of essential oil (18.5-300 µg/ml). The result revealed that the essential oil showed concentration dependant activity against cell line. The IC50 value of MCF-7 cell line was 90.6 µg/ml. This may be due to the presence of important terpenoid. This is the first kind of report against invitro anticancer activity of H. suaveolens essential oil.