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Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.04, No. 07)

Publication Date:

Authors : ; ; ;

Page : 2047-2050

Keywords : ADR and it can be managed by stopping of the above drugs. So; clinical pharmacist plays a major role in detecting; monitoring and managing of ADRs.;

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Spiranolactone and Eplerenone were belongs to the class of potassium sparing diuretics where as Torsemide belongs to the loop diuretic class, they mainly acts by blocking the function of aldosterone hormone to retain the sodium and excrete potassium. By irrational use of these drugs induced dyselectrolytemia like hyperkalemia and hyponatremia. A 55 years female patient was admitted in cardiology department with the chief complaints of drowsiness and slow response to commands by using of the diuretics (Spiranolactone , Eplerenone and Torsemide) causes the electrolytes induced hyperkalemia and hyponatremia. These electrolytes abnormalities will causes the cardiac arrhythmias , muscle paralysis and sometimes death also. Whereas both rechallenge and dechallenge was done and the ADR assessment scales like Naranjo and WHO gives certain ADR and it can be managed by stopping of the above drugs. So, clinical pharmacist plays a major role in detecting, monitoring and managing of ADRs.

Last modified: 2017-07-31 00:40:41