FORMULATION AND DEVELOPMENT OF ZOLPIDEM TARTRATE FAST DISSOLVING FILMS BY USING SODIUM CMC

Drug is used for the treatment of insomnia and some brain disorders. The purpose of the present work is to formulate and enhance the drug release of zolpidem tartrate by the incorporation of suitable polymer in the oral dissolving films (OTF) for use in specific populations viz. geriatrics and patients experiencing difficulty in swallowing. The oral dissolving films loaded with zolpidem tartrate were prepared by solvent evaporation method using sodium CMC by adding suitable plasticizer glycerin. The prepared oral dissolving films were evaluated for drug content, weight variation, thickness, pH, folding endurance, In vitro drug release and stability studies. The evaluation parameters of zolpidem tartrate were found to be satisfactory in terms of drug content, thickness and pH. Comparison of the dissolution profiles of zolpidem tartrate oral dissolving films in phosphate buffer (pH 6.8). Effective drug release was achieved for zolpidem tartrate by way of preparation of oral dissolving films by solvent evaporation method. ZOL7 showed the highest drug release at the 10 min time point.The ZOL7 oral dissolving film with higher amount of superdisintegrant CCS and SSG showed fastest onset of drug release. Keywords: Zolpidem tartrate oral dissolving films, solvent evaporation method and Dissolution rate.