METABOLIC EFFECTS OF CHRONIC ALCOHOL INTOXICATION

Background. Chronic alcoholization is a common pathology. Aim of study: to study biochemical parameters in the liver and blood serum of rats with chronic alcohol intoxication (ChAI). Material and methods. The number of biochemical indices was determined in the blood serum and liver after administration of 25% solution of ethanol at the dose of 3.5 g / kg of body weight twice a day for 14 and 29 days. Amino acid mixture «Trivamin» was administered at the dose of 600 mg / kg and «Thalerin» - at the dose of 125 mg / kg. Results. For certain marker indicators the severity of metabolic abnormalities in ChAI depends on the duration of alcohol exposure, for others the activity of GGT changes in more complicated manner, what reflects the activity of adaptation and regulatory mechanisms. Hormonal imbalance with the involvement of different parts of the endocrine system was detected. The administration of «Trivamin» and «Tallerin» to the rat partially attenuated the effect of ChAI on the liver. Conclusions. It has been established that ChAI leads to metabolic imbalance at different regulatory and structural levels.