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COMPARATIVE ANALYSIS OF VITAMIN D RECEPTOR GENOTYPE FREQUENCIES IN BELARUSIAN POPULATION AND IN PATIENTS WITH CARDIOVASCULAR DISEASES OF GRODNO REGION

Journal: Journal of the Grodno State Medical University (Vol.15, No. 3)

Publication Date:

Authors : ; ; ; ; ;

Page : 338-343

Keywords : polymorphism of VDR gene; BsmI; FokI; vitamin D; arterial hypertension; ischemic heart disease;

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Abstract

The aim of the study was to perform a comparative analysis of the frequencies of genotypes by BsmI (B / b) (rs1544410) and FokI (F / f) (rs2228570) alleles of the VDR gene in Belarusian population and in patients with CVD (arterial hypertension (AH), ischemic heart disease (IHD)) of Grodno region. Material and methods. 182 patients with CVD were examined. BsmI and FokI of the VDR gene were determined by polymerase chain reaction. For comparison, the results of the genotypes analysis of 719 ethnic Belarusians, including 89 Belarusians of Ponemanje region, were used. Results. Genotype bb and allele b of polymorphic BsmI locus of the VDR gene were more frequent (p<0.05) in the group with CVD (41.2% and 63.2%, respectively) and in citizens of Ponemanje region (42.9% and 65.3%, respectively) than in general population (31.4 % and 56.7%, respectively). Patients from Grodno region with genotype bbff of the VDR gene have an increased risk of developing CVD (OR = 2.3 (95% CI 1.32, 3.93) and AH (OR = 2.92 (95% CI 1.55, 5.496), patients with genotype bbFF also have an increased risk of developing CVD (OR = 1.74 (95% CI 1.06, 2.83) and CHD (OR = 2.14 (95% CI 1.14, 4.03). Conclusions: Significant differences in frequency distribution of genotypes BsmI and FokI of the VDR gene in patients with CVD of Grodno region compared to general population data were established.

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Last modified: 2017-09-19 16:54:59