FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF FEXOFENADINE HYDROCHLORIDE

In the present work, mouth dissolving tablets of fexofenadine HCl were designed with a view to enhance patient compliance by direct compression method. The present work studied the effect of superdisintegrants on release rate of fexofenadine HCl in the form of fast disintegrating tablet. For the present study range of superdisintegrants in their different concentrations, were used. The superdisintegrants used were Magnesium stearate, Microcrystalline Cellulose, Cross Povidone, Sodium Starch Glycolate,and Cross Carmellose Sodium. The blends were prepared by direct compression technique. The tablets were evaluated for hardness, thickness, friability, drug content, weight variation and in-vitro drug release studies in pH 6.8. Keywords: Fexofenadine hydrochloride, Mouth Dissolving Tablets, Magnesium Stearate, Microcrystalline Cellulose, Cross Povidone, Sodium Starch Glycolate,and Cross Carmellose Sodium