ASSOCIATION OF C-REACTIVE PROTEIN AND METABOLIC SYNDROME IN RELATION TO AGE, GENDER AND DURATION

Objective: To determine the association between C-reactive protein and metabolic syndrome in relation to age gender and duration. Patients and Methods: This cross sectional descriptive study of six months study was conducted at Liaquat University Hospital Hyderabad from 01-July-2013 to 31-Dec-2013. All the patients of 20 to 60 years of age presented with symptoms of metabolic syndrome for more than 01 year duration were admitted and evaluated for C-reactive protein. The data was analyzed in SPSS and the frequency and percentage was calculated. Results: During six month study period, total 142 patients (93 females and 49 males) with metabolic syndrome were evaluated for C-reactive protein. Majority of patients were from urban areas 103/142 (72.5%). The mean ±SD for age of patients with metabolic syndrome was 42.63±8.82. The mean age ±SD of patient with raised CRP was 45.86±7.21. The mean circumference for males and female patients with raised CRP was 49.53±3.73 and 46.89±4.32 while the TG for males and female patients with raised CRP was 187.82±4.61 and 191.32±3.84 whereas the HDL-C for males and female patients with raised CRP was 30.74±2.31 and 26.75±2.51 respectively. The mean ± SD for systolic and diastolic blood pressure of males and female patients with raised CRP was 145±3.32 and 100.52±2.61 while the fasting blood glucose level for males and female patients with raised CRP was 135.42±2.53 and 146.53±6.54 whereas the CRP for male and female patients with raised CRP was 3.82±1.21 and 5.9±1.73 respectively. The majority of subjects from 40-49 years of age group with female predominance (p = <0.01) while the CRP was raised in 98(69%) patients in relation to age (p=<0.01) and gender (p=<0.01) respectively. Of 98 subjects with raised CRP 73 were females and 25 were males (p=0.01). Conclusion: The raised CRP was observed in patients with metabolic syndrome. Key Words: Metabolic syndrome, C-reactive protein