EVALUATION OF CYTOTOXIC ACTIVITY OF DICHOLOROMETHANE (DCM) AND METHANOL (MEOH) EXTRACT OF ROOT BARK OF CAPPARIS DECIDUA

The present study was conducted to evaluate the cytotoxic activity of different extracts of root bark of Capparis decidua (Capparidaceae). The root barks of Capparis decidua were collected from village Kirri khaisore Tehsil Pahar pur, Dera Ismail Khan; shade dried and ground into fine powder. The weighed plant material was then extracted with dichloromethane and methanol in triplicate for 72 hours by the process of successive maceration. The filtrate obtained was concentrated under reduced pressure at 30 °C using rotary evaporator. Brine shrimp lethality bioassays and MTT colorimetric assay were carried out on the extracts to assess the cytotoxic activity. Dichloromethane extract showed moderate brine shrimp lethality activity, while this activity was not shown by methanol extract. Both extract showed no cytotoxic activity. Keywords: Capparis decidua, cytotoxicity, Brine Shrimp