Injection Oxytocin versus Injection Methergine in Active Management of Third Stage of Labour

Post partum hemorrhage is one of the most common causes of maternal death through out the world and is preventable with effective management of labour. Objectives: To assess effect of injection oxytocin vs. injection methergine in active management of third stage of labour. Materials & Methods: Two groups simple randomized design used on 50 parturient women. Group 1 contains 25 parturient women and injection oxytocin 10 IU given IM within one minute of birth of baby and group 2 given injection methergine 0.2 mg. IV at the delivery of anterior The main outcome measures were amount of blood loss, duration of third stage and other maternal outcome.Results: Injection oxytocinMethergine are equally effective, with duration of third stage of labour (P=0.2455), third stage blood loss (P=0.6603) . Majority 50(100%) of women showed no variation in temperature, pulse, and respiration except observation of diastolic blood pressure at 60 min. of delivery. Higher incidence of nausea & vomiting in patients given. InjectionMethergine. Study reveals 76% women in Group I & 64% women in group II experienced mild abdominal pain & 8% women in gr. I & 16% women from group II experienced severe abdominal pain.Conclusion:The study concluded that intramuscular oxytocin and intravenousMethergineare most effective drug in reducing the 3rd stage blood loss. This reduction in blood loss reduce incidence of post partum anemia, infection and hence maternal mortality and morbidity.